But it does not change the fact that lisp is not easily accessible for most people, and that particular limitation of lisp is why it will not be 'the next big thing'.
On a personal note, I don't think that using DSLs is good programming practise. It is my opinion that this makes your code too specific to you and you force anyone trying to understand your code to first learn a new language - the one you just invented.
It's like comparing Seth Godins writing to the writings of Kant. There was a time when I was in philosophical mood and I bought the original German version of a book by Kant. Kant is often described as one of the great thinkers, but he sure is not one of the great writers. His sentences are long and unwieldy and it's very difficult to understand what he's trying to say. Seth Godin writes plainly, however, and he communicates his ideas clearly.
The core purpose of reading both their writings is to gain in knowledge, and when the sentence structure of one writing is so obscure that one can't even parse the sentence, then this purpose is not being achieved.
Writing a DSL is the same thing - if nobody else understands what you wrote, then, though you may have succeeded in communicating your meaning to the computer, you have failed in communicating to anybody else who may want to improve your code. And that second part of things is also an important part of programming.