Very aggressive screening at the outset, with all the submissions in an easy to read list.

At my last job, we would ignore every single submission that didn't have a cover letter. If the cover letter has even the slightest red flag; for example if it doesn't mention anything specific about the company, then onto the next one. The next step would be an equally aggressive phone screen.

It's ruthless and you might miss out on some great candidates, but the time wasted by interviewing the wrong people is a killer.