Extism does not yet support writing the plugins (our term for Wasm guests) in python. I have been working on javascript support[1] and I think I could use a similar strategy to support python. If you are at all interested in following along or helping out you should join our discord.[2] I just started a #python-pdk channel there.

[1] https://github.com/extism/js-pdk [2] https://discord.gg/mAADpt9r