"Ego Trip", MacDara Ó Raghallaigh. An hour of solo fiddle and foot tapping. Best album I have heard in heard in ages. But then, he occasionally double-stops, so I guess it's not purely monotonic...
Anyway, I suspect the answer to your question is no, if done properly. That is to say, I believe if the computer caught all the rhythmic, dynamic, and pitch subtleties of the music, the music would still be interesting, if perhaps harder on the ears.
And don't think that you need more than one instrument
or more than one voice to make real music. Pretty much
every musical instrument and every person's voice is a
source of polytonic sound.