Keep in mind you will need a air bearing spindle that runs at high x10k RPMs to actually use them.
For smaller holes we zap them in the material with lasers.
That's the absolutely small I could find, though I suspect specialty vendors have even smaller ones. You can find MMC's other micro drill bits here: https://www.mcmaster.com/micro-drill-bits/
My only experience with these was in school where we used 0.25mm micro end mills (like a drill bit that cut sideways) to cut our own PCBs. A small desktop micro CNC would just cut the traces out of a blank copper clad board. That's when I learned how easily these bits can break, so even though they're not that expensive you go through them very quickly.
Holy shucks... How are they even manufactured? I imagine they have really precise grinding tools to make the flutes..
I frequently use a bigger size for fabricating reinforced epoxy with paper clips serving as rebar. Gyros Micro Drill Bit Set of 25#57 Drill Bits–Small Drill Bits for Jewelry, Plastic and Soft Metal–Mini Twist Drill Bit Set for Pin Vise Hand Drill, Rotary Tool - Carbon Steel Wire Gauge Drill Bits
.1mm is about 4 thou (.004"), or the thickness of a piece of paper. I'm being a little loose with the numbers here, but they're in the ballpark.
[1] https://sphinx-tools.ch/en/catalog-products-eshop/drilling-a...
The middle sized bits are occasionally useful to (carefully!) finger-drill a tiny hole through a plastic part. They're rigid, very sharp, but pretty breakable if you're not careful.
The 0.1mm bit is so small that it's upsetting even to look at. I've never taken it out of the case.
I would not expect you to be able to use bits this small without special machinery.
I've used similar 0.8mm drill bits by hand, and they were fragile enough.