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If you are on iOS there is a per-app setting where you can disable cellular data for a particular app. It's possible you inadvertently turned that on for Twitter - Its a mistake I've made before and convinced myself I had a bug in my app.

Wow, that was it. No idea how that happened.

Could it be something OS config related? I recently migrated phones without "upgrading" (I do this every other upgrade) and realized I put in some draconian lockdowns on my old phone that prevented me from seeing Twitter at all in the browser. New phone worked fine.

Have you checked settings > cellular to see if you might have accidentally denied mobile data usage for that particular app?