'hybrid vigor' is when you take two inbred genetic lines and cross them together to pick up some of the genes you accidentally deleted while selecting for something else.
For instance the modern Irish Wolfhound was created by an nobleman who, worried about the breed dying out (there hadn't been a wolf in GB in over a hundred years), bought every wolfhound he could get his hands on, and crossbred them with mastiffs and Danes to build up a healthier population (while maintaining stature). Then he selected back to phenotype and went from there.
One of the groups trying to save the American Chestnut is doing the same thing, though I think their methods are recklessly optimistic. They've crossed residual chestnut populations with Asian chestnuts and then back breeding those to try to get just the blight genes and nothing else.
I say reckless because the smartest thing to do would be to identify the resistant genes and test each tree to see if it's carrying the gene. Instead they are infecting every tree and culling the ones that are susceptible. Effectively making a petri dish in which the blight can learn to infect resistant trees over time.
In some ways I think the GMO people may be the less insane of the two, and I'm very much not a fan of the transgenic surface area for pathogen adaptation across species.