I have two goals: avoid any long term effects from getting Covid myself, and avoiding giving Covid to my immune compromised spouse. At the moment, the only way to achieve either of those things is to avoid getting Covid at all. With better treatments to either prevent contracting Covid after an exposure, or better treatments to reduce the risk of long Covid, I’d start to consider my risk budget. For now it’s “as close to no risk of contracting Covid as possible”. With better prevention and treatment strategies I’ll probably consider some things that I won’t do now, but I don’t see a realistic scenario where I ever return to conferences, and I imagine I’ll probably continue masking in public essentially forever.
In a lot of ways, the situation today is harder than it was a couple of years ago. Vaccines help prevent infection but not to a degree where you can really rely on that as a first line of defense, and they barely reduce the risk of long Covid, if at all. On top of that, masking is rare, people no longer test, and if they do they no longer avoid going out into public with an active infection. In any reasonably sized office there’s basically no chance you won’t be exposed to Covid at least several times per year now.