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CDNs are mostly about having large numbers of servers in convinent locations not software. The software is the easy part.

That said, wikipedia documents its CDN setup which is all open source at https://wikitech.wikimedia.org/wiki/Caching_overview which might be of interest to you.

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One thing I really appreciate about Wikimedia is the openness and quality of documentation for their infrastructure (which can be found at https://wikitech.wikimedia.org/wiki/Wikimedia_infrastructure).

It's an excellent resource for anyone curious to learn about their systems. I wish more organizations would embrace transparency and open-source principles as much as Wikimedia does.

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