I am creating a fully digital comic in HTML & CSS only. Even the illustrations are CSS generated pixel art. In case someone's interested you can find it here : https://drdru.github.io/twc/twc_save_aryn/02_on_the_way_to_k... .
If you need inspiration you can take a look at this as well made using REXPaint. https://preview.redd.it/vxfohcwxywt71.png?width=1458&format=...
It's all ASCII art so in theory one should be able to convert it to HTML. I have a project to make a story using REXPaint to HTML in a near future.
If you need more info, feel free to contat me raising an issue on github.