I am assuming that CoffeeScript should be able to add new syntax where the need arises, as the number of CoffeeScript users is probably still pretty low and able to adapt to change.

From what I can tell, CoffeeScript - and the Javascript/Node world - would really benefit from something like F#'s workflow/computation-expression syntax, which will take a fairly straight-forward readable statement and behind the scenes de-sugar the hell out of it into a bunch of closures.

http://en.wikibooks.org/wiki/F_Sharp_Programming/Computation...

EDIT: search for "De-sugared syntax" on this page for an example.