Well it depends on what you mean by "quite a bit of work"! Wick rotate, focus on a finite volume of spacetime, and discretize the spacetime. That's all. The first step changes a difficult-to-sample distribution exp( i S ) into an easy-to-sample exp( – S ). The other two steps keep you from needing infinite RAM.

The discretization and finite-volume approximations may be removed by doing calculations with different spacings and volumes and extrapolating. The Wick rotation is more subtle, and typically means only some observables are accessible. To study the path integral with real time causes a very difficult sign problem [essentially: you need an exponentially large number of samples in order to get cancellations under control], which is why real-time quantum dynamics is an exciting potential application of quantum computers.