The general gist of "yes, but" comments in this thread and in the post itself is that not every application works.

This is true and real, and we as a community should stop saying "yeah, it's a weird distro". We should look at it and say "Alpine (and Gentoo, and Nix, and Arch, ...) is a separate OS". Closely related to the OSes of other Linux distributions, but still separate, because of a different ABI and API.

I have written about it here: https://dottedmag.net/blog/linux-is-not-os/