Even in the example given, the $22.50/hour rate is just the break-even rate with child-care workers at the minimum wage. If you push them up to a living wage of 75k/yr, the listed cost doubles. Add again people wanting child care costs to not just be break-even but to make working feel worth it, and it probably doubles again.
It's just a very hard business with difficult scaling. It gets better after age 2, when you can increase your student/staff ratios, for what that's worth.