One major issue I do see coming from the C# side is "well how do I do this then?!", which often the answer is "you don't, because you don't need to" or "well what if it's more performant to do it mutably!" well then thankfully F# can absolutely do that.
If you keep an open mind it's really a very clean and simple language, but in an age where half of development is importing 8 well known libraries, not being the main supported language is a major weakness.