My point being, if most of the program is slowed down by a slew of wasted CPU cycles (costly abstractions, slow interpreted language…), there's a good chance what should have been obvious bottlenecks get drowned in a see of underperformance. They're harder to spot, and fixing them doesn't change much.
So before you even get to actual optimisation, your program should be fast enough that actual optimisations have a real impact. And yes, actual optimisation should be done quite rarely. But first, we need to make sure our programs aren't as slow as molasses. See https://www.youtube.com/watch?v=pgoetgxecw8