The association between mitral valve prolapse and anxiety is well-known. However this physical difference is completely ignored when it's mild. In the general population, mild prolapse is seen as a common thing.
However there are also diseases caused by genetic mutations which cause both mitral valve changes and also a whole set of body problems including chronic pain, elasticity, vascular problems etc. The underlying causes are so under-researched that an easily fixable problem tied to a gene becomes a progressive disease over a lifetime which is damn hard to diagnose. You suddenly see that too few resources are dedicated to actually understand and solve medical problems instead of treating symptoms when they get severe.
Plus... coffee is a pretty good way to kick off anxiety and we know it for at least a century I guess.