One of my projects (https://markdoc.dev/) is a Markdown dialect that supports custom tags and a React renderer. I recently experimented with implementing a parser for it in Rust in order to increase performance. My Rust-based parser is significantly faster than my existing JavaScript parser, but then I have to serialize the AST in order to move it from Rust to JavaScript. I'd like to implement the entire processor in Rust, but I need to let users define custom tags in JavaScript, and the overhead of going back and forth is far from ideal.
I'm hopeful that the recently-ratified Wasm GC proposal—which introduces managed structs and arrays that don't cost anything to pass between the Wasm environment and JavaScript—will help a lot. But it's going to take awhile for Wasm GC features to land in LLVM and be properly supported in Rust.