OK, just to give one example... my co-founder is married, and her husband is in graduate school. So either he'd have to interrupt his education to come with her, or he'd have to accept her running off to the opposite side of the country for three months, chasing a dream that he might or might not be fully sold on. We honestly haven't had the discussion yet, but my gut feeling is that this would be a very hard sell. And YC make it clear that they expect all (or at least a majority) of the co-founders to make the trip.

Also, we have a local incubator (Triangle Startup Factory) that is (potentially) an option for us, which would not require any relocation at all.

Given that, it's not exactly a "no brainer" to apply to YC. I'm not saying we won't do it (either now or in a future cycle) but it's not necessarily an easy decision.