East of 280 doesn't really denote anything about danger to me, as I don't recall those areas being any more dangerous than the rest of SF. If they deliver to Tenderloin and not there I highly doubt it's for the reason you're alluding to
If my original example is what we went with, you could because tenderloin is smack dab in SF, and it would be clearly discriminatory to pick up passengers from everywhere in SF except that one neighborhood.