You can't give out loans really without fractional banking either. I mean you can. But not really.
Mortgages are collateralized, and business loans can be secured with assets or equity. I suspect the majority of bank loans are mortgages (?). Interest rates do not need to be high without fractional banking, since loans can be secured.
… and ~25% of the Feds entire balance sheet is mortgage securities.
But, I guess if your goal is less people being able to get mortgages and loans, maybe it will be a good thing!
Banks, bolstered nightly with USD loans from this Fed, could not.