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Do you have any good literature on Aspirin and LC? Not a doubter, actually I have LC myself.

I do not. I have my personal anecdote and experiences with common painkillers and LC. I've had it since January 2021 so there wasn't really anything known when I started taking aspirin outside of the many years of research as mentioned in OP's article. Here's my experience so far.

https://jondouglas.dev/long-covid/

I've swapped aspirin about a year in for nattokinase and have noticed much better management. I still take aspirin here and there, but NK is doing its job.

https://pubmed.ncbi.nlm.nih.gov/36080170/

https://www.webmd.com/covid/news/20221207/microclots-may-exp...

https://pharmd.substack.com/p/frequency-asked-questions-natt...

Hope that helps you.

EDIT: I heard about triple anticoagulant therapy but never realized aspirin is included in it. Check out this study here: https://www.researchsquare.com/article/rs-2697680/v1

Just adding a +1 for long covid and aspirin, aspirin + CBD cream (Momma Canna Cream, I think only available in Canada) was a game changer for me! I rubbed the CBD cream into my head and neck and took bayer "daily" low dose aspirin till I started to feel normal again (brain fog cleared).

How long did it take?

Seemed like it was never going away, 9 months in to "long covid" I kept saying "this needs to clear soon, it should clear soon" - I was going nuts because of the brain fog (end of 2021 into 2022). Did a lot of research, saw the clotting and inflammation research so I put myself on aspirin and CBD, after about a week and a half/2 weeks I noticed a slight improvement, about 3 months thereafter things were getting back to normal. To be perfectly honest, I'm not sure I've really ever fully recovered from covid, but hard to say if it's covid, getting older, stress. Never the less, I feel personally confident that aspirin + cbd helped.

The degradation effect paper is authored by among others James Yu, Kate Hsu, Shinder Chen (employees of NK producer) and Ayako Ishii (company involved in NK supply chain). Take it with a grain of salt.

While not Aspirin alone Etheresia Pretorius has been pioneering research on microclots in LC. In a recent preprint they used Aspirin and a bunch of other stuff:

>The anticoagulant regime included dual antiplatelet therapy (DAPT- Clopidogrel 75mg + Aspirin 75mg) once a day, and a direct oral anticoagulant (DOAC- Apixaban) 5mg twice a day. A proton pump inhibitor (PPI) pantoprazole 40 mg/day was also prescribed for gastric protection.

Results:

>..Following completion of treatment, each of the different symptoms resolved in the majority of patients.

https://www.researchsquare.com/article/rs-2697680/v1

I was surprised to read recently that Metformin has been a helpful therapy for LC. It's also an old drug (not as old as Aspirin of course!) with a surprising number of therapeutic use cases.

The micro-clots in covid and long-covid are fibrin clots, not platelet clots.

There is endless documentation and photos of this, it looks like tangled spaghetti.

Every report of aspirin vs covid is wishful thinking, it does nothing.

The amount of misinformation with covid and long-covid is astounding.

This article talks about how aspirin works and what was learned. Inhibiting the COX enzyme and reducing the activation of platelets can indirectly help prevent the formation of fibrin clots.

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