Secure Computing with Zymbit's D35
jeffgeerling.com
jeffgeerling.com
After realizing that this seems to primarily be intended for cryptocurrency applications, though... yeah, that seems about par for the course.
The accelerometer and temperature sensors / settings could make it a little more difficult, since the heat sink is directly above the processor and one would need to get through it to gain access to the pins.
But it could be possible with some creative solutions. Probably not if all tamper protections are active though.