We know humans can be captured or gripped by any number of involuntary phenomena, particularly when it becomes a social effect and in effect reduces individual conscious control in favor of the social locus. So that lens seems fairly valid on its face.
This also took place during extraordinarily harsh times even for that particular point in history. There had been massive floods and damage to crops, with food prices soaring, in addition to newly-spreading syphilis. There was probably a fairly strong unconscious sense of loss of control in the first place.
Hm. Mycotoxins?
Be warned on clicking yonder hyperlinks least ye be similarly afflicted!
https://www.youtube.com/watch?v=cRIfsFefatg
Varily they did try to summon a hero during those dark days: https://www.youtube.com/watch?v=Nx-x_1lIXh4
But lo, some tried to escape by way of sea: https://www.youtube.com/watch?v=u9eSnSBP1Po
Some say this evil lasted as late as 1576: https://www.youtube.com/watch?v=e6LOWKVq5sQ
The idea of mass psychogenic illness is pretty well known and even happens today.
You’ll read about some school where a bad smell comes up, some kid faints and then suddenly the class is on their way to the hospital, only to find out there was no exposure.