Title should include “in healthy lean individuals” which was the study title. Without that it sounds like the study contradicts a huge body of evidence which it doesn’t.
https://www.youtube.com/watch?v=U1f9g9Y1wm0
They both lost some weight, although the brother who was on the low-carb diet ended up virtually pre-diabetic.
"Low-carb" dude removed all fruits and vegetables. He didn't do low-carb, he did no-carb - in his own words: "meat cheese eggs".
The whole clip just reeks of b.s. though, neither of these guys would be getting air time if the results weren't click-bait controversy fodder. The b.s. incentives are clear.
[1]"Prediabetes happens when your blood glucose levels are higher than normal, but not high enough to be diagnosed as diabetes. Prediabetes usually occurs in people who already have some insulin resistance."
So, it doesn't sound right that he would be pre-diabetic when his blood glucose levels would be low. Seems that doctor made the assumption that because his blood insulin was low, his body would just stop producing it at some point, and that's not how it works.
[1]https://my.clevelandclinic.org/health/diseases/22206-insulin...
It's been known for decades (outside of the HN reality distortion field) that excess accumulation of intramyocellular lipids in skeletal muscle is the primary underlying mechanism driving Type 2 Diabetes, so that's pretty much the outcome you'd expect.
There's hundreds of thousands of people currently having success with no-shellfish diets to manage their shellfish allergy; yet these people don't go around using words like "reversed" or "cured" in reference to their allergy, the way keto people do with insulin resistance. And most of those keto people having apparent success would fail an OGTT (a test that actually measures insulin sensitivity, unlike fasting BG/insulin or HbA1c) if they took one.
If I have an unclogged bathtub (normal metabolism) - I can fill the tub quickly with water (a carbed up meal) with water and then it drains out.
The problem is when you combine high fat with low fiber carbs (donuts, meat AND potatoes, cake, peanut butter) - you clog the tub and dump water into the tub.
Low carb diets are associated with higher all cause mortality - and are not sustainable for the planet.
Weightloss improves various metabolic biomarkers, including markers of insulin sensitivity, and so the fact that people who lose weight following a particular intervention (low-carb or whatever else) see such improvements is unsurprising. That's why looking at subjects who are already lean is much more informative: it gives a better sense of the metabolic effects of the dietary intervention itself, not confounded by weightloss.
> Without that it sounds like the study contradicts a huge body of evidence which it doesn’t.
What huge body of evidence? All of the people drastically restricting their carbohydrate consumption so they can cheat on their fasting BG and HbA1C tests? Give those people an Oral Glucose Tolerance Test and measure their insulin response in real time, and the vast majority of them would fail, especially the ones on high (saturated) fat diets: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602127/
> Our finding of a strong relationship between VO2max and relatively unsaturated IMCL pools in controls and athletes points to a role of exercise in decreasing the amount of saturated fat within the IMCL store. The association of insulin resistance with the accumulation of saturated IMCLs, even within a healthy control population, could suggest an early involvement in its pathogenesis and provide a reason why combined exercise and diet are effective therapeutic options in the early stages of insulin resistance.
High-fat diets are atrocious for insulin sensitivity.
Sorry I’m not going to whip a metaanalysis together for you to refute your flippant HN comment. The evidence is out there, apparently you’re one of these people that turned your conclusions into a religion. That’s fine, please don’t waste other people’s time asking for evidence as if you’re willing to have a good faith discussion.
Use a search engine.
The assumption here is that this is a temporary/reversible condition. At least it was in my case.
For the record, I did a low carb diet for 6 months. I was in ketosis for much of it, with temporary periods of break when it was unavoidable (during travel, lack of food options, social setting). I feel exogenous ketones helped me with the process of getting back in ketosis.
>Wait, I cut carbs out almost completely, why are my numbers getting worse?
Because you're eating more fat, and probably more saturated fat in particular, which means more intramyocellular lipids, and hence, you're becoming more insulin resistant. Cutting the carbohydrate consumption only masks the IR, at best. The simplest explanation is that "phsiological IR" is just plain-old insulin resistance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602127/
> OGTT is useless
It's probably the best cheap test for clinically diagnosing insulin resistance: https://pubmed.ncbi.nlm.nih.gov/23327814/
Fasting BG, fasting insulin, and HbA1C only measure blood sugar control, which severe carbohydrate restriction can sometimes obtain, but without actually reversing the underlying pathology of IR. An OGTT, by contrast, measures your insulin response to a bolus of glucose in real time.
Fat also has the lowest thermic effect, a paltry 2-3%. Besides having the most calories per gram (9 vs 4 for protein or carb), it provides by far the cheapest, easiest calories for your body to digest.
>provides by far the cheapest, easiest calories for your body to digest
I mean metabolically cheap and easy. Your body expends the least energy digesting fat (2-3%, or 2-3 calories worth of energy for every 100 fat calories you consume), and the most digesting protein (>20%). Add to that the fact that fat has more than twice the calories per gram that carbohydrate and protein do, and it's little wonder why so many people fail with keto.