The PicoSystem itself can be purchased from its creator, pimoroni: https://shop.pimoroni.com/products/picosystem
https://github.com/fhoedemakers/PicoSystem_InfoNes
It’s still in early stages, no sound and no save points, but thoroughly cute and addictive nonetheless!
All of our products meet the REACH and RoHS requiements for restricted and hazardous materials.
TL;DR It's fine.
Use of PCB as a human user interface started in hobbyist world, because it was cheap and easy to create sturdy front panels and was good enough for creating prototypes, but it was never meant for mainstream commercial use in this way - as PCBs even if they meet RoHS, still can contain dangerous chemicals - like flame retardants.