I'm in Germany, and you may have heard on the news that we have a lot of refugees/immigrants from places like Syria who we are trying to integrate into our society. A lot of them are very qualified. Some of them have since gotten advanced grad degrees from German universities.
And then we may not be able to hire them or have to severely restrict them at work, e.g. when we use Qualcomm chips which are under US export restrictions.
I don't have a very deep point to make, except to say that the human costs and the stings that come with the state of the world can go far indeed.