File systems are drivers and user space software shouldn’t really see the difference.
There is no way to make NTFS case insensitive either, it being case insensitive in Windows is a Windows implementation detail.
But again, that is a OS implementation detail thing, the underlying file system is still case preserving.
[1] https://www.collabora.com/news-and-blog/blog/2020/08/27/usin...
Perhaps if I ran some software off it I might find some more issues but, overall quite little. The difference in speed is immense though.