For python it routinely has trouble with pip, default locations that pip use, virtual envs break, reshimming doesn't work half the time, I can't even remember all the other issues I've had.

For node it's more of the same, old versions of node were so broken that installing them through asdf doesn't work unless you build directly from source. Reshimming doesn't work half the time, global packages can't be found, idk what else. tons. It's just ridiculous to see when _every_ other language works fine in asdf.