CRISPR-Cas-amplified urinary biomarkers for cancer diagnostics

This is the key sentence in the summary and it is f'ing clever:

> Since endogenous biomarkers such as shed proteins or nucleic acids can be limited by either their abundance or stability in circulation, engineered ‘synthetic biomarkers’ are in development that leverage the biochemistry of the diseased microenvironment to amplify the production of analytes with improved signal-to-noise ratios

As far as places to start with human genome editing, adding better debugging output seems a good one.

(in mice)