Absolutely. I know from personal experience that much of what remains of independent journalism in India, as well as some NGO work (long under government scrutiny) is conducted through Signal and Element.
https://telecom.economictimes.indiatimes.com/news/dangerous-...
Besides Pegasus and such and the interception issues with SMS, might be as well due to HUMINT and the weaknesses in verifying fingerprints.
Probably it would be best for people in some of these countries to do their work offline.