Like a lot of PKD concepts, it defies a simple explanation (by design). It hits on many of his common themes: consciousness, what it means to be human, the shifting and blurry nature of reality, the merging and melding of different minds, etc.
On its surface, it's a religion based on the Messianic "Wilbur Mercer" character, and the shared vision of him that people can enter through the Empathy Box. But then the book explores whether Mercer, and that shared vision in the Empathy Box, is actually "real" or "fake", in a way that closely mirrors the exploration of androids vs humans.
The Mercer box was something people could use to plug in and feel something, sort of like a Mega Church, rock concert, etc. that moves you; something positive in an otherwise negative place. But it's a programmed feeling, it's not real.
It contrasts with the hunting-and-retiring-androids thing, in that real people can't feel things unless they plug into a program, and are feeling something wholly artificial -- so how is that really any different from the 'droids?
Too real :p
How did he predict my addiction to World of Warcraft in 1968?