You don't have to be large or even get sued for them to affect you. Gyu Beats had a video where he recreated Aphex Twin's "Ageispolis" from scratch. And Die Antwoord's label copyright-claimed all revenue from that video because Die Antwoord sampled Ageispolis (unedited, with permission). It's likely an automated copyright claim, but does that make it any better?
If Aphex Twin copyright-claimed the song that would be another thing. But this is like if someone else sampled Ghosts 34 and Lil Nas X claimed original copyright ownership of the sample.