I've only started reading Pynchon lately. I'd seen too many comparisons to James Joyce, and I struggled and gave up on Ulysses at least 4 times.
Anyway, I picked up a copy of V at a second-hand bookshop recently and, so far, I'm enjoying it. It's definitely densely packed and not a quick read, but I think he's just carrying on the post-modernist tradition of Proust and Joyce.