I suppose that’s a personal design and a trade off that you and others need to make.
I live in a “red state” and am described by several of the groups you mention and don’t feel the government nor community is hostile to me. I think it’s hard to understand beforehand what is hostile and how much hostility is worth peace of mind, prosperity, etc. That being said, I think it’s possible that everywhere has some unpleasant aspects and I wish that it wasn’t a “pick your poison” situation of having to choose between $5k/month rent and piles of human poo and not having to travel out of state for an abortion.