Yes. Browsers typically initiate a TLS (TCP) connection to port 443 for HTTP1/2, and then upgrade to HTTP/3 based on the Alt-Svc header.
https://developer.android.com/guide/topics/connectivity/cron...
QUIC actually lets you migrate between connections (because the packets are identified by a connection ID in each UDP packet rather than a 5-tuple). Clients will typically re-test a connection occasionally and downgrade as needed for this to work.