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I'd take a few hundred over a few. My concern, as another commenter suggested, is mostly around radical changes without any longevity in testing or understanding. Even though a lot of our "natural" foods were created via artificial selection, it's a process that happened over many generations. When it comes to food and nutrition, my gut tells me to generally prefer slow over fast.

Personally I also think there is a big difference between selective breeding, and distilling foods into constituent parts in order to recombine in various ways. Maybe I'm overly paranoid, but I don't fully trust humans to understand and play that part of nature just yet.

I think he is concerned about revolutionary change, i.e. processed food and artificial suppliments. Bread that is not actually bread.

Not evolutionary change - a. different variery of wheat in your bread.

That's their point, that we should probably not be eating "modern foods".