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> Histological classifications become less and less relevant

What do you mean by "histological classification" because every interpretation I can think of is very incorrect.

I meant that every cancer diagnosis is done by a pathologist who describes the looks of the cell/tissue and is trained to assign a cancer classification to it. This is currently changing to genetic testing where the underlying mutation (that is causing the tissue changes) is identified. AFAIK the tissue classification is still the gold standard for most cancer types, but I am positive that this will be completely replaced by the new methods. Medicine will not put the cells under a microscope anymore but into a DNA analyzer instead.

That's incorrect.

If you mean diagnosing the type of cancer (e.g. clear cell renal cell carcinoma) we've already been using molecular markers for over a decade now.

Since you mention "describing the look": mitotic rate and local staging (depth of invasion, lymphovascular invasion, perineurial invasion) matter far more than any DNA/type of cancer and this isn't changing at all nor will it ever change.

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