Haven't had any issues with bitwarden or uBlock origin in Orion that I have noticed. There is perhaps a little delay when you click the extensions in orion to their ui loading but thats about it.

Have been using it for a few months now and its become my default browser on macOS and IOS. As I understand it for IOS the killer feature is extensions... I haven't got round to trying this yet.

On a side note it has by far the best native tree style tabs I have used and until firefox has an equivalent I won't be going back. (yes I used sideberry extension but like I said orions native implementation beats it hands down).