This does come at a cost: hotkeys are usually a mess, especially if you have a second language layout (Cyrillic in my case), sometimes working differently dependent on layout, and hotkeys positions are typically optimised for QWERTY.
Interestingly, all Dvorak advantages on regular keyboard become severe disadvantages on smartphones: Dvorak is optimised for alternating hands while typing as much as possible, but when you type with one thumb, you constantly need to move your finger from one side of a keyboard to another. One could probably come with a screen keyboard layout optimized to type with one finger, but I'm yet to see such keyboard.