the 16" will have a slot for discrete cards (I don't think it will be a PCIe slot but could be wrong).
[0]: https://frame.work/blog/introducing-the-framework-laptop-16
Direct link to the pinout PDF: https://github.com/FrameworkComputer/ExpansionBay/blob/main/...
It's a 4th-gen x8 interface, so there are limits to what "any old GPU" might be capable of performance-wise, but creating a passthrough-port accessory seems possible.