DISCLAIMER: all advice given here is given under the assumption that you did your research, and that you have good reasons why you're interested in psychedelics as a tool. They're a powerful tool, and powerful tools cut both ways. Turning into a new age woo head is a real risk, I've seen it happen to the staunchest of sceptics, no one is immune. Do your research, people, test your drugs, and be careful.

I think this research sort of puts the kibosh on microdosing as a paradigm, which has been my intuition all along. If you really want the potential from psychedelics, microdosing is sort of the wrong approach I always thought.

What you want to do instead is take them maybe once a year at most, though just one trip in a lifetime can be sufficient depending on your situation, then spend the following period of plasticity putting a lot of effort into changing your life the way you want to, establish habits, pick up new techniques, whatever it is you want to accomplish. You will learn faster, be more able to establish habits. And that learning is forever. You can reap the benefits for the rest of your life, completely sober.

I have done extensive self experimentation with microdosing of various psychedelics and the results were fairly clear to me. I felt smarter, and overall pretty great. I felt like I was making all these brilliant connections. But whenever there was an objective source of truth available, it became clear this was all an illusion, I was struggling to make connections that would otherwise be obvious to me, and that made it feel more significant than it was.

Chess, for instance, was one such source of truth. Played a couple long games against evenly matched opponent(rated and everything). Made a complete ass of myself. Played easily 3-400 elo points below my usual level. And all the while thinking I was playing brilliantly and calculating deep lines, I was really just imagining lines that never worked. My working memory was terrible. Time management completely off.