I predict people's answers to this question will come from experience with memoization. Here's mine: I kept trying to get nix to build tensorflow locally, so that I would get the avx512 benefits of the big, but gpu-less machine I had. I hadn't realized some other derivation had already downloaded tensorflow from online cache, so didn't have avx512 enabled. I kept making shells, trying tensorflow, seeing it doesn't have support. The solution was to tell nix to disregard the nix store, in order to force the local build. This experience has left me with the concrete feeling that the nix store is full-on state, and I the user must be aware of it.