Recently switched to keto, which has the primary function of lowering insulin levels and reduction of feelings of hunger. And within 2 months I'm 18 lbs down.
It's not simply a matter of Calories in/calories out, the kinds of calories you eat matter. 2000 calories of donuts vs 2000 of beef are vastly different nutrient profiles and you will have corresponding health effects accordingly.
> potentially impacting energy metabolism
CICO is mostly true if you already have a balanced diet, if you eat 2000kcal of ultra processed food you'll have side effects you wouldn't have with a cleaner diet. The body is a fine tuned machine, it doesn't process 100kcal of sugar the same way it processed 100kcal of broccoli
Also the way calories are "counted" in exercise is absolutely bogus for individuals because it rarely takes into account their physiology and basically uses made up numbers of various exercise types.
https://open.oregonstate.education/aandp/chapter/26-1-body-f...
> Figure 26.1.8 – Edema: An allergic reaction can cause capillaries in the hand to leak excess fluid that accumulates in the tissues.
https://www.scientificamerican.com/article/science-reveals-w...