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Signal to noise ratio. When the admin of a server thinks the ratio of another server is too low, the admin will block it.

What's the definition of too low? Up to the admins of that server.

That's the problem. It's enough when people choose themselves whom to follow.

It's not enough if those people's posts are flooded with low quality replies.

That seems to be only a problem for a few people with a very high follower count or for viral tweets. Both are quite rare relatively speaking.