>I wonder if there is potentially an issue with them in aggregate. Such that the dose of any single chemical isn't problematic but all of them together with similar effects causes a problem.

I've been wondering about this a lot in recent years. Particularly in regards to medications/pharmaceuticals but also environmental containments/traces (which can include pharmaceuticals of course), pair with this what we are just starting to understand about plastics exposure and pervasiveness and I really wonder why more health research and workplace safety resources aren't being directed to look at compound and long term exposures.