I'd say it entirely depends on what stuff you're looking for. I'd pass on something like a Denali because the electronics and added trim pieces seem to be the most unreliable parts. The powertrain will be fine.
If anything my personal preference would be a mid-trimmed spec that skips things like a HUD, self driving, and leather trimmed door panels. Forward collision detection, a great sound system, and a platform that's mechanically dependable is my go-to.