> The Colemak layout was designed with the capabilities of modern keyboards in mind

But it wasn't! Modern keyboard is precisely what the author describes in the following bullet points: split and ortho (though it shouldn't be linear, our fingers have different lengths). He also forgot to mention utilizing your strongest fingers with a thumb cluster instead of that dumb long spacebar

None of the popular QWERTY alternatives have been designed with a proper ergo keyboard in mind, not to mention all the other modern keyboard features like home row modifiers.

(I don't know of any layout development algo and its resulting layout that takes those things with an actually typed training corpus into accounts, but would be happily proven wrong)