Not being combative, but can you justify that statement with data? It just seems implausible to me, given that the moonshot companies tend to employ a lot more people. Yes, relatively few companies become "big deals", but those companies (Adobe, MS, Google, Facebook, Apple) are the ones that actually employ most of the people in the industry.
Aside from 37Signals, what lifestyle businesses are (a) less stressful and (b) more lucrative than a shoot-for-the-moon startup? If it's a technology business, it's something that will be obsolesced rapidly unless you keep moving (e.g Yousendit being obsolesced by Dropbox), so where's the "lifestyle" in that?
It seems that your best options are either (a) join a startup or (b) work for a large company. The no man's land in between seems to be the highest stress and worst returns, with no prospect of your ship ever really coming in.