How the Y chromosome makes some cancers more deadly for men

Being a black male athlete can gives you an increased chance of developing a certain type of kidney cancer. The full explanation is listed below, but the gist is black people have more chance to have sickle cell trait and during high intensity training your kidney starve for oxygen and this damages a certain gene that is a palindrome and thus hard to correct for the immune system and thus grows into a cancer:

https://www.youtube.com/watch?v=j7WGP6sJBLk

This seems counter intuitive to me. Men having the Y chromosome, but also have and X. Women having two XX but only one is active. So unless those extra Y chromosome genes are causing issues I’m not sure why it would be different.

https://en.m.wikipedia.org/wiki/X-inactivation

I think x-inactivation is on a cell by cell level so it could be having 2 X chromosome would be an advantage, though why escapes me.

Well that sucks.